QAU Obtains Two More Third Class National New Veterinary Drugs

2018-10-18 10:00            

Recently, Ministry of Agriculture and Rural Areas of China has issued the No. 15 announcement, approving the product of Tolfenamic Acid (TA) API and the injectable veterinary drug of Tofinal Acid declared and submited by Qingdao Agricultural University(QAU)  as the third class national new veterinary drugs  ((2018)the new veterinary drug certificate Numbers being 20 and 21 respectively). The moditoring period for these approved new drugs is 3 years, and the product quality standard, instructions and labels have also been released. Developed by Professor Hao Zhihui and her team of AU, the new drug can be applied to both human and veterinary markets. It has a very broad market potential.

Tolfenamic Acid is a member of the anthranilic acid derivative (or fenamic acid) class of NSAID drugs discovered by scientists at the Medica Pharmaceutical Company in Finland. It is a COX inhibitor with anti-inflammatory, analgesic and antipyretic effects. By inhibiting cyclooxygenase (COX), it reduces the conversion of arachidonic acid (AA) to prostaglandins (PGs), a inflammantory mediator, and plays an anti-inflammatory and analgesic role. Numerous studies show that TA can be absorbed rapidly in animals, and it reaches the maximum blood concentration within 1 to 2 hours after injection. TA enters the human body and distributes in almost all tissues. The drug is excreted in the body almost entirely in the form of TA glycine and glucuronic acid conjugate through urine (90%), and without severe specific toxic reaction. The new drug has been successfully transformed into Shandong Xinde Technology Co., Ltd., Hebei Weiyuan Animal Pharmaceutical Co., Ltd., Servier (Qingdao) Bio-Pharmaceutical Co., Ltd., Qilu Animal Health Products Co., Ltd., Nanjing Witt Animal Medicine Co., Ltd, and has been implemented actual production and application.

Professor Hao Zhihui and her team of QAU have long been committed to the research on the acquisition of  active ingredients and the creation of new medicine with maximum efficacy. The research and development of veterinary drugs has become a major advantage and highlight of the research work in our univerisity. In recent years, the team have hosted more than 30 projects at various levels, including national key R&D programs and international cooperation and exchange programs. It has led the development of more than 20 new drug varieties and obtained new veterinary drug certificates. The research results were published in Drug Delivery, Pharmacutical Research and Microbial Cell Facteries, etc. It also published more than 60 papers in SCI; obtained 32 authorized invention patents; published 8 books including Pharmacy; hosted and as the main performer, formulated 11 national and industrial standards; received 9 research awards including Shandong scientific and technological awards.  Previously, the new drugs such as Lianpu Shuangqing Granules, Lianpu Shuangqing Powder and Echinacea Granules, which were designated by Hao Zhihui and his team, have been approved as the national new veterinary drugs and have been successfully transformed.

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