Prof. Ding Fei's Group Publishes Cover Paper at Royal Society of Chemistry again

2017-11-01 14:42            

Recently, Prof. Ding Fei's research group titled Pesticide Molecular Designing of the School of Plant Medicine, Qingdao Agricultural University (QAU), published relevant results regarding chiral pesticide research in the journal Molecular Biosystems of Royal Society of Chemistry( RSC). The article was selected as the Front Coverof the current issue by the editor. This is the third time the group’s paper has appeared at the cover of the journal of RSC. Peng Wei, a member of Prof Ding’s group, is he first author, Prof. Ding Fei being the corrsesponding author and QAUas the first completion unit.

Chirality is the basic attribute of nature, and is closely related to life phenomena. When the chiral substances enter the environment, under the action of asymmetrical factors,the enantioselectivity exists in almost all biological processes such as absorption, distribution, migration, transformation, degradation and metabolism etc.,,which thus incurs that the bioactivities of different enantiomers display obvious disparities. At present, the environmental risk assessment of a large number of chiral pesticides is based on raceme form, which does not fully consider the enantioselectivity differences of these chiral compounds, so it is difficult to accurately reflect the objective facts. The potential hazards of different optical isomers on environmental media and organisms can be evaluated only when the toxic effects of chiral pesticides are studied at the enantiomer level.

In the previous work, with the help of biophysical and computational chemistry methods, the group explored the biological effects of several chiral racems on different target enzymes, and elucidated their interaction mechanisms. The results of the study were published in various academic journals, such as Mol. BioSyst. (2015, 11, 1119-1133), RSC Adv. (2016, 6, 1826-1843), Phys. Chem. Chem. Phys. (2016, 18, 11959-11971, cover article), J. Photochem. Photobiol. B: Biol. (2017, 171, 75-84). On the basis of this, the research group cooperated with the counterpart laboratories of Tianjin University to separate the typical chiral pesticides which are widely used at present, and obtained the high-purity optical isomers. The root causes of enantioselectivity of chiral pesticides in the environment were clarified at both static and dynamic scales, and the micromechanism of the biochemistry phenomenon was analyzed at the molecular/atomic level.

In view of pesticide pollution on the ecological environment, especially the fact that the negative impact on the environment of chiral pesticide organisms isstill not clear, this research result not only helps to real the complex mechanism of chiral pesticide poisoning effect, but also provides a useful clue for the comprehensive evaluation of the enantiomeric toxicity of other chiral organic pollutants. Therefore, this research was recommended by the editor in chief of the journal. On October 24th, the paperwas published as a cover paper in Molecular Biosystems(2017,132226-2236), a journal of RSC.

This project was supported by Tianjin Chemical Engineering Collaborative Innovation Center and Tianjin Modern Drug Delivery and Functional High-efficiency Key Laboratory, and was financed by Shandong Natural Science foundation , Shandong College Science and Technology planning Project, Open Fund of New Pesticide Creation and Development State Key Laboratory and QAU’s High-level Talents Research Fund.

 

 

 

Translated by Cheng Jie,Proofread by Ding Shuting

 

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