Ding Fei Published a Cover Paper in an A1 Journal of Royal Society of Chemistry

2016-04-05 09:24            

Recently, Professor Ding Fei of School of Agriculture and Plant Protection of Qingdao Agricultural University, published a research paper about target enzyme conformational flexibility in Physical Chemistry Chemical Physics, a A1 journal of Royal Society of chemistry , and the paper was chosen by editor to be the cover story of the current journal .This is the second time that Professor Ding Fei published a cover paper in Royal Society of chemistry. The first author is Professor Ding Fei, and Qingdao Agricultural University is the first holder and the unique correspondent.

In biomass, protein / enzyme and other biological macromolecules can form the specific space-conformation by polypeptide chain, and this conformation has flexibility and dynamic nature. Exploring the influence of conformation’s flexibility and dynamic nature on biological recognition can help people understand the important physical and chemical process in body.

Under the support of National Natural Science Foundation of China and the "Twelfth Five-Year" national science and technology support plan, professor Ding Fei’s research group explored the influences of target enzyme’s structural flexibility and dynamic nature on biological recognition. Relevant results were published in a number of academic journals, such as Mol. BioSyst.(2014, 10, 2509-2516, cover article), Eur. J. Pharm. Sci.(2015, 76, 119-132), RSC Adv.(2016, 6, 1826-1843), and so on. Recently, on the basis of the above study, this research group discussed the influences of homologous protein’s amino acid sequence differences on target enzyme identificate triphenylmethane veterinary drugs in detail and analyzed relative contributions of the same amino acid residue in polypeptide chains for biological recognition. This research’s result was published in Phys. Chem. Chem. Phys(2016, 18, 6595-6606).

In the latest study, this research group combined the computational chemistry with Biological physics technique, discussed the potential influences of intracellular target enzyme conformational flexibility on flavonols biological activity, and revealed the essential reason why the bioavailability of human body to flavonoids alcohols is so low. In view of diverse biological activity of natural products and broad application prospects, many international counterparts, such as professor Tajmir - Riahi, Canada, thought that this study provided a new method for the exploration in molecular level about Microscopic nature that human body has low availability to bioactivator.

Character profile: Ding Fei, male, born in June 1982, Nanjing, Jiangsu, graduated from the pesticide science major of China Agricultural University, and received a doctorate degree in science in 2014.During his doctorate study, he went to the Massachusetts institute of technology for cooperative research on Protein modification and drug toxicology and was guided by Professor Gerald N. Wogan and Professor Steven R. Tannenbaum, both of whom are academicians of the U.S. National Academy of Sciences. Then, he did postdoctoral research about new pesticide molecular design in China Agricultural University. In September 2014, as a "third level" of talent, he jointed School of Agriculture and Plant Protection of Qingdao Agricultural University to be a professor. In recent years, professor Ding Fei has published more than 40 research papers in international SCI source journals, including two cover papers and more than 20 A1 papers. His papers were quoted more than 700 times by others and many papers go into "ESI highly cited papers" the top 1. Meanwhile, professor Ding Fei is also an editor of international SCI source journals, including Food Research International, Current Medicinal Chemistry, Current Drug Metabolism and Current Topics in Medicinal Chemistry. Besides, he is also a reviewer of more than 40 SCI source journals in Europe and America, such as the American chemical society and Royal Society of chemistry.

Physical Chemistry Chemical Physics is a top journal in international physical chemistry field. Published by the royal Chemical society, it has bigger influence on Computational chemistry, Chemistry agricultural chemicals and other fields. This journal is A1 publication of SCI with impact factors of 4.493.

 

Translated by Lin Pengcheng  edited by Gao Xiuxue

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